Analysis of codon usage bias of exonuclease genes in invertebrate iridescent viruses

In this study, we analyzed the CUB in 10 invertebrate iridescent viruses exonuclease genes by calculating and comparing the nucleotide contents, effective number of codons (ENC), codon adaptation index (CAI), relative synonymous codon usage (RSCU), and others. The results revealed that IIVs exonuclease genes are rich in A/T. The ENC analysis displayed a low codon usage bias in IIVs exonuclease genes. ENC-plot, neutrality plot, and parity rule 2 plot demonstrated that besides mutational pressure, other factors like natural selection, dinucleotide content, and aromaticity also contributed to CUB. The findings could enhance our understanding of the evolution of IIVs exonuclease genes.PMID:38402641 | DOI:10.1016/j.virol.2024.110030

Source: Virology - February 25, 2024 Category: Virology Authors: Ye şim Aktürk Dizman Source Type: research