Osmotic stress induces the formation of migrasome ‐like vesicles
In this study, we report the formation of migrasome-like vesicles enriched in tetraspanin 4 and containing cytoplasmic components in response to hypoosmotic stress. When migrating cells were subjected to hypoosmotic stress, vesicles with a size distribution of 0.5 to 2 μm formed on the retraction fibers, and vanished in a few minutes. The vesicles are rich in cholesterol, and their number was reduced when cells were pretreated with lipoprotein-deficient serum. The formation of migrasome-like vesicles upon hypoosmotic stress may provide biophysical cues regardi ng the cellular response to this external stimulus in cells and tissues.
Source: FEBS Letters - Category: Biochemistry Authors: Koki Yoshikawa,
Shogo Saito,
Tetsuya Kadonosono,
Masayoshi Tanaka,
Mina Okochi Tags: Research Letter Source Type: research