Effects of human herpesvirus 6B reactivation on cognitive function in cord blood transplant recipients: a prospective multicenter study
Int J Hematol. 2024 Feb 26. doi: 10.1007/s12185-024-03714-2. Online ahead of print.ABSTRACTThis prospective multicenter study aimed to determine the effects of human herpesvirus-6B (HHV-6B) reactivation on central nervous system (CNS) function in cord blood transplant (CBT) recipients. Our focus was to track HHV-6B reactivation and evaluate its association with delirium and cognitive function, specifically in the domains of verbal memory, attention/processing speed, and quality of life (QOL). A cohort of 38 patients participated in this study. Of the 37 patients evaluated, seven (18.9%) developed delirium, with six of these cases emerging after HHV-6B reactivation (median lag, 7 days). Evaluation of verbal memory showed that the final trial score for unrelated words at 70 days after transplantation was significantly lower than that before preconditioning (P = 0.004) among patients (n = 15) who experienced higher-level HHV-6B reactivation (median or higher maximum plasma HHV-6 DNA load for participating patients). Patients without higher-level reactivation did not show significant declines in verbal memory scores. QOL was assessed using the 36-item Short-Form Health Survey, and the social functioning score 1 year post-transplantation was significantly lower in patients who experienced higher-level HHV-6B reactivation than in those who did not. Our findings suggest that higher-level HHV-6B reactivation can detrimentally affect certain cognitive functions in CBT recipients.PMID:...
Source: International Journal of Hematology - Category: Hematology Authors: Masao Ogata Kumi Oshima Kuniko Takano Rie Kawano Yasunori Ueda Takashi Imamura Yukinori Nakamura Takahiro Okada Tomomi Toubai Toshimitsu Ueki Nobuhiko Uoshima Hiroyuki Ishida Akihito Shinohara Sachiko Seo Takahiro Fukuda Masatoshi Inagaki Source Type: research