Broad-Spectrum Defenders: γδ T Cells Take on a Multitude of Immune Challenges

J Leukoc Biol. 2024 Feb 27:qiae044. doi: 10.1093/jleuko/qiae044. Online ahead of print.ABSTRACTIn a recent PNAS article, Guo et al. investigate γδ T cell antigen specificity in mice and humans, in which they show that γδ T cell antigen specificity is not constrained to one epitope. Rather, γδ T cells recognize a broad range of diverse antigens containing similar chemical structures or properties. In this News and Views, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.PMID:38411623 | DOI:10.1093/jleuko/qiae044

Source: Journal of Leukocyte Biology - February 27, 2024 Category: Hematology Authors: Julian J Freen-van Heeren Source Type: research