Antenatal administration of extracellular vesicles derived from amniotic fluid stem cells improves lung function in neonatal rats with congenital diaphragmatic hernia.

The severity of pulmonary hypoplasia is a main determinant of outcome for babies with congenital diaphragmatic hernia (CDH). Antenatal administration of extracellular vesicles derived from amniotic fluid stem cells (AFSC-EVs) has been shown to rescue morphological features of lung development in the rat nitrofen model of CDH. Herein, we evaluated whether AFSC-EV administration to fetal rats with CDH is associated with neonatal improvement in lung function.

https://www.jpedsurg.org/article/S0022-3468(24)00110-6/fulltext?rss=yes

Source: Journal of Pediatric Surgery - February 27, 2024 Category: Surgery Authors: Rebeca L. Figueira, Naghmeh Khoshgoo, Fabian Doktor, Kasra Khalaj, Tasneem Islam, Nazgol Moheimani, Matisse Blundell, Lina Antounians, Martin Post, Augusto Zani Tags: Original Article Source Type: research