Modeling Doxorubicin Pharmacokinetics in Multiple Myeloma Suggests Mechanism of Drug Resistance

Conclusions: A reliable PK model describing DOXO uptake and release in MM cells has been successfully developed. Significance: The proposed PK model, once integrated with DOXO pharmacodynamics, has the potential of allowing the study and the optimization of DOXO treatment strategies in MM.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research