Best practices and recommendations for grossing and reporting of post-immunotherapy nephrectomy specimens: a single-institution experience of 70 cases

The gross handling of and reporting of renal cell carcinoma in the setting of neoadjuvant immune checkpoint inhibitor therapy presents unique challenges, and there is little known about the spectrum of histologic changes that can be seen in this setting. We studied 70 cases of RCC, status post immunotherapy and nephrectomy at our institute and devised a standardized grossing protocol to help assess pathologic response. Our protocol includes sampling a complete cross section of the largest diameter of tumor with additional sections from areas of gross extrarenal involvement.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: urological pathology Source Type: research