Therapeutic index of targeting select chromatin complexes in human cancer patients

Curr Opin Genet Dev. 2024 Feb 23;85:102162. doi: 10.1016/j.gde.2024.102162. Online ahead of print.ABSTRACTAberrant chromatin regulation can promote the initiation and progression of human cancer. An improved understanding of such mechanisms has resulted in the identification of cancers with an enhanced dependency on specific chromatin regulatory proteins relative to nonmalignant cell types. Hence, targeting of such complexes with small molecules has significant therapeutic potential in oncology. In recent years, several drugs have been developed and evaluated in human cancer patients, which can influence tumor biology by reprogramming of chromatin structure. In this review, we summarize several of the known mechanisms that endow cancer cells with a powerful dependency on chromatin regulation that exceeds the requirements for normal tissue homeostasis. We also summarize the remarkable small-molecule inhibitors that exploit chromatin regulator dependencies with a clear therapeutic benefit in human cancer patients.PMID:38401489 | DOI:10.1016/j.gde.2024.102162
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Source Type: research