Aerobic exercise modulates the striatal Erk/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease

CONCLUSION: 4 weeks of aerobic exercise can effectively alleviate the development of L-DOPA-induced dyskinesia and improve motor function in PD mice. The related mechanism may be related to the inhibition of striatal Erk/MAPK signaling pathway overactivation by aerobic exercise, but this change did not occur selectively in D1-MSNs.PMID:38395109 | DOI:10.1016/j.brainresbull.2024.110906

Source: Brain Research Bulletin - February 23, 2024 Category: Neurology Authors: Fangyuan Zhou Longwei Wei Yinhao Wang Wei Chen Source Type: research