Involvement of peptidylarginine deiminase 4 in eosinophil extracellular trap formation and contribution to citrullinated histone signal in thrombi

CONCLUSIONS: As in NETosis, PAD4 can catalyze the formation of EETs. Inhibition of PAD4 decreases EET formation, supporting the future utility of PAD4 inhibitors as possible antithrombotic agents.PMID:38395360 | DOI:10.1016/j.jtha.2024.02.010

Source: Thrombosis and Haemostasis - February 23, 2024 Category: Hematology Authors: Kimberly Martinod Frederik Denorme Severien Meyers Marilena Crescente Stijn Van Bruggen Mathias Stroobants Patrick M Siegel Ramesh Grandhi Katharina Glatz Thilo Witsch Source Type: research