ER remodeling via lipid metabolism

Trends Cell Biol. 2024 Feb 22:S0962-8924(24)00023-0. doi: 10.1016/j.tcb.2024.01.011. Online ahead of print.ABSTRACTUnlike most other organelles found in multiple copies, the endoplasmic reticulum (ER) is a unique singular organelle within eukaryotic cells. Despite its continuous membrane structure, encompassing more than half of the cellular endomembrane system, the ER is subdivided into specialized sub-compartments, including morphological, membrane contact site (MCS), and de novo organelle biogenesis domains. In this review, we discuss recent emerging evidence indicating that, in response to nutrient stress, cells undergo a reorganization of these sub-compartmental ER domains through two main mechanisms: non-destructive remodeling of morphological ER domains via regulation of MCS and organelle hitchhiking, and destructive remodeling of specialized domains by ER-phagy. We further highlight and propose a critical role of membrane lipid metabolism in this ER remodeling during starvation.PMID:38395735 | DOI:10.1016/j.tcb.2024.01.011

Source: Trends in Cell Biology - February 23, 2024 Category: Cytology Authors: Wonyul Jang Volker Haucke Source Type: research