Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets

ConclusionThe effect of lamotrigine in reducing quetiapine concentration is only significant for patients using quetiapine IR tablets who are treated with lamotrigine doses  >  200 mg/day. Because of high variability in the interaction effect, TDM of quetiapine should be recommended during co-prescription of high-dose lamotrigine.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research