A Case-Based Narrative Review of Pregnancy-Associated Atypical Hemolytic Uremic Syndrome/Complement-Mediated Thrombotic Microangiopathy

Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy (TMA), caused by uncontrolled activation of the alternative complement pathway in the setting of autoantibodies to or rare pathogenic genetic variants in complement proteins. Pregnancy may serve as a trigger and unmask aHUS/complement-mediated TMA [aHUS/CM-TMA] which has severe, life-threatening consequences. It can be difficult to diagnose aHUS/CM-TMA in pregnancy due to overlapping clinical features with other TMA syndromes including hypertensive disorders of pregnancy.

Source: Kidney International - February 24, 2024 Category: Urology & Nephrology Authors: Michael Che, Sarah M. Moran, Richard J. Smith, Kevin Y.M. Ren, Graeme N. Smith, M. Khaled Shamseddin, Carmen Avila-Casado, Jocelyn S. Garland Tags: review Source Type: research