Interferon-gamma release assay conversion after M. tuberculosis exposure specifically associates with greater risk of progression to tuberculosis: a prospective cohort study in Leicester (UK)

Tuberculosis infection (TBI) comprises a spectrum of asymptomatic Mycobacterium tuberculosis (Mtb) infection states, with varying risk of developing to active tuberculosis disease (TB) [1] that reflects underlying heterogeneity of the dynamic balance between pathogen and host. Reliable identification of subgroups at greatest risk for targeted TB preventive treatment (TPT) is a critical component of the global TB prevention strategy [2].
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research