Cell-based influenza vaccines: an effective vaccine option for under 60-year-olds

Wien Klin Wochenschr. 2024 Feb;136(Suppl 2):35-42. doi: 10.1007/s00508-024-02327-3. Epub 2024 Feb 23.ABSTRACTThe population < 60 years of age is also affected by a significant disease burden from seasonal influenza. It carries a high economic burden, mainly driven by influenza-associated productivity losses in the working population. Conventional egg-based influenza vaccines may experience reduced effectiveness due to antigen adaptation in eggs. In contrast, cell-based influenza vaccines are less likely to be affected by antigenic adaptations to the host system and showed better effectiveness in individuals 4-64 years old over several seasons compared to conventional egg-based influenza vaccines under real-world conditions. Preferential use of cell-based influenza vaccines, as opposed to conventional egg-based vaccines, could reduce the burden of influenza-related symptoms on individuals and alleviate the economic impact on the German population < 60 years of age.PMID:38393348 | DOI:10.1007/s00508-024-02327-3
Source: Wiener Klinische Wochenschrift - Category: General Medicine Authors: Source Type: research