Repurposing DNase I and alginate lyase to degrade the biofilm matrix of dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa grown in artificial sputum medium: In-vitro assessment of their activity in combination with broad-spectrum antibiotics

Lung infections are a leading cause of morbidity and mortality in patients with cystic fibrosis (CF). The sticky mucus that accumulates in their airways provides a favorable environment for microorganisms to form biofilms that lead to chronic infections[1]. Biofilms are bacterial aggregates encased in self-produced matrix mainly composed of extracellular DNA (eDNA), polysaccharides and proteins[2,3].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research