Efficacy of antibiotic prophylaxis for reducing capsular contracture in prosthesis-based breast surgery: a systemic review and meta-analysis

AbstractAntibiotics Prophylaxis to prevent capsular contracture in prosthesis-based breast surgery is common in clinical practice. However, there is currently a dearth of high-quality evidence concerning the effectiveness of antibiotic usage in this field. To identify all pertinent studies prior to January 2023, a comprehensive literature search was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and Medline databases. The extracted data was then subjected to meta-analysis. Fourteen studies were retained in the analysis. According to the results, perioperative antibiotic prophylaxis did not reduce the risk of capsular contracture (RR 1.15, 95% CI 0.82 –1.59,p = 0.55) or surgical-site infection (RD 0.01, 95% CI − 0.01 to 0.03,p = 0.59) compared to nonantibiotic prophylaxis. There was no statistically significant difference between extended antibiotic prophylaxis and perioperative antibiotic prophylaxis in terms of preventing capsular contracture, whether calculated by patient numbers (RD 0.01, 95% CI − 0.01 to 0.02,p = 0.87) or by total procedures (RD 0.00, 95% CI − 0.00 to 0.01,p = 0.88), or controlling surgical-site infection (RR 1.05, 95% CI 0.77–1.44,p = 0.27). Additionally, topical antibiotic irrigation did not decrease the risk of infection (RR 0.61, 95% CI 0.34–1.08,p = 0.29) and capsular contracture, regardless of patient number (RR 0.41, 95% CI 0.27–0.63,p = 0.18) or total number of procedures (RR 1.29, 95% ...
Source: Updates in Surgery - Category: Surgery Source Type: research