Imaging flow cytometric detection of del(17p) in bone marrow and circulating plasma cells in multiple myeloma

CONCLUSIONS: The "immuno-flowFISH" imaging flow cytometric method could detect del(17p) in plasma cells in both bone marrow and blood samples of myeloma patients. This method was also able to detect gains and losses of chromosome 17, which are also of prognostic significance. The lowest levels of 0.009% (bone marrow) and 0.001% (blood) for chromosome 17 abnormalities was below the detection limit of current FISH method. This method offers potential as a new means of identifying these prognostically important chromosomal defects, even when only rare cells are present and for serial disease monitoring.PMID:38379463 | DOI:10.1111/ijlh.14248

Source: International Journal of Laboratory Hematology - February 21, 2024 Category: Hematology Authors: Thomas I Mincherton Stephanie J Lam Sarah E Clarke Henry Y L Hui Jacques A J Malherbe Hun S Chuah M Hasib Sidiqi Kathy A Fuller Wendy N Erber Source Type: research