Revealing underlying regulatory mechanisms of LINC00313 in Osimertinib-resistant LUAD cells by ceRNA network analysis

CONCLUSIONS: Our results suggest that the LINC00313/miR-218-5p/COL1A1 axis potentially contributes to osimertinib resistance through the PI3K/Akt signaling pathway, providing novel insights into the molecular mechanisms underlying acquired osimertinib resistance in LUAD. Additionally, our study may aid in the identification of potential therapeutic targets for overcoming resistance to osimertinib.PMID:38377935 | DOI:10.1016/j.tranon.2024.101895

Source: Translational Oncology - February 20, 2024 Category: Cancer & Oncology Authors: Dandan Ding Chenguang Xu Jufeng Zhang Ying Zhang Lipeng Xue Jingjing Song Zhiming Luo Xiaoyu Hong Jian Wang Weicheng Liang Xingyang Xue Source Type: research