Vitamin D status and variable responses to supplements depend in part on genetic factors in adults with cystic fibrosis

It has been known for decades that many people with cystic fibrosis (PwCF) and pancreatic insufficiency (PI) do not achieve normal vitamin D status based on blood concentrations of 25-hydroxyvitamin D (25OHD) despite taking fat-soluble vitamin supplements with good adherence [1 –5]. We consider these patients a distinct CF phenotype and refer to them as “vitamin D non-responders” [1]. They contrast distinctly from the situation with vitamins A and E because supplementation with those fat-soluble vitamins accompanied by adherence is invariably successful, despite the presence of severe PI [4,6].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research