Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over 50 human disorders, including Alzheimer ’s and Parkinson’s diseases. Increasing evidence implicates misfolded protein...

Source: Molecular Neurodegeneration - February 20, 2024 Category: Neurology Authors: Dillon J. Rinauro, Fabrizio Chiti, Michele Vendruscolo and Ryan Limbocker Tags: Review Source Type: research