Preoperative factors that predict pathologic nodal involvement in early-stage HER2+  breast cancer: selecting cT1cN0 patients for treatment with neoadjuvant chemotherapy versus upfront surgery

ConclusionPatients with cT1cN0 breast cancer have a 32.5% likelihood of nodal metastases, with higher incidence with younger age, LVI, multifocality/multicentricity, and abnormal axillary ultrasound. The presence of these factors may identify the patients who would benefit from treatment with neoadjuvant chemotherapy.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research