Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus

In conclusion, while the effects of long-term CR on anxiety-type behavior were inconclusive, it mitigated the memory deficit related to aging, which was accompanied by an increase in hippocampal 8OHdG in DG. Future studies should investigate whether the benefits of CR would remain if the restriction were interrupted after this long-term protocol.PMID:38336097 | DOI:10.1016/j.nlm.2024.107902

Source: Neurobiology of Learning and Memory - February 9, 2024 Category: Neurology Authors: Izabelle Dias Benfato Ana Carolina Silvares Quintanilha Jessica Salles Henrique Melyssa Alves Souza Barbara Dos Anjos Ros ário Jose Ivo Ara újo Beserra-Filho Alessandra Mussi Ribeiro Luciana Le Sueur Maluf Camila Aparecida Machado de Oliveira Source Type: research