Mitochondrial dysfunction due to miR-210/Drd5/ROS axis is a potential mechanism of heart failure

Guoqing et al. recently reported that the absence of the dopamine receptor D5 (Drd5) in the mouse heart induces mitochondrial oxidative stress, then leading to heart failure [1]. This discovery suggests that Drd5 is a promising therapeutic target for the treatment of heart failure. However, the mechanism by which Drd5 is regulated in heart failure remains unclear.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research