Excess fermentation and lactic acidosis as detrimental functions of the gut microbes in treatment-naive TB patients

DiscussionExcessive fermentation and lactic acidosis likely characterize TB patients’ disturbed gut microbiomes. Since lactic acidosis strongly suppresses the normal gut flora, directly interferes with macrophage function, and is linked to mortality in TB patients, our findings highlight gut lactate acidosis as a novel research focus. If confirmed, gut acidosis may be a novel potential host-directed treatment target to augment traditional TB treatment.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research