Real-Time Genomic Epidemiologic Investigation of a Multispecies Plasmid-Associated Hospital Outbreak of NDM-5-Producing Enterobacterales Infections

Bacteria that cause healthcare-associated infections (HAIs) can harbor plasmids encoding genes conferring antibiotic resistance to commonly prescribed antimicrobial agents, leading to pathogens that are well adapted to the hospital environment. Infections with antimicrobial-resistant pathogens are associated with poor patient outcomes and have limited options for therapy [1]. Horizontal plasmid transfer represents the primary mechanism by which antibiotic resistance genes can be shared between different bacterial species [2].

Source: International Journal of Infectious Diseases - February 17, 2024 Category: Infectious Diseases Authors: Nathan J. Raabe, Abby L. Valek, Marissa P. Griffith, Emma Mills, Kady Waggle, Vatsala Rangachar Srinivasa, Ashley M. Ayres, Claire Bradford, Hannah M. Creager, Lora L. Pless, Alexander J. Sundermann, Daria Van Tyne, Graham M. Snyder, Lee H. Harrison Source Type: research