The Immune System in Neurological Diseases: What Innate-like T Cells have to Say

The immune system classically consists of two lines of defense: innate and adaptive, both of which interact with one another effectively to protect us against any pathogenic threats. Importantly, there is a diverse subset of cells known as innate-like T cells that act as a bridge between the innate and adaptive immune systems and are pivotal players in eliciting inflammatory immune responses. A growing body of evidence has demonstrated the regulatory impact of these innate-like T cells in central nervous system (CNS) diseases, and that such immune cells can traffic into the brain in multiple pathological conditions, which can be typically attributed to the breakdown of the blood-brain barrier (BBB).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research