Adipose tissue composition determines its computed tomography radiodensity

ConclusionsThis study unveils the connection between abdominal adipose tissue radiodensity and its chemical composition. Because the radiodensity of the fat around the surgical site is associated with surgical difficulty, it is important to understand how adipose tissue composition affects this parameter. We conclude that fat tissue with a higher content of various phospholipids and waxy lipids is more CT radiodense.Clinical relevance statementThis study establishes the connection between the CT radiodensity of adipose tissue and its chemical composition. Clinicians may use this information for preoperative planning of surgical procedures, potentially modifying their surgical approach (for example, performing partial nephrectomy openly rather than laparoscopically).Key Points•Adipose tissue radiodensity values in computed tomography images taken prior to the surgery can potentially predict surgery difficulty.•Fifty-three human specimens were analyzed by advanced mass spectrometry, molecular imaging, and machine learning to establish the key features that determine Hounsfield units ’ values of adipose tissue.•The findings of this research will enable clinicians to better prepare for surgical procedures and select operative strategies.Graphical abstract
Source: European Radiology - Category: Radiology Source Type: research