Aberrant B cell receptor signaling in circulating na ïve and IgA < sup > + < /sup > memory B cells from newly-diagnosed autoantibody-positive rheumatoid arthritis patients

CONCLUSION: Collectively, the isotype-specific analysis of multiple key components of the BCR signalosome identified aberrant BCR signaling responses in treatment-naïve autoantibody-positive RA patients, particularly in naïve B cells and IgA+ memory B cells. Our findings support differential involvement of dysregulated BCR signaling in the pathogenesis of autoantibody-positive and autoantibody-negative RA.PMID:38350168 | DOI:10.1016/j.jaut.2024.103168

Source: Journal of Autoimmunity - February 13, 2024 Category: Allergy & Immunology Authors: Stefan F H Neys Judith W Heutz Jennifer A C van Hulst Madelief Vink Ingrid M Bergen Pascal H P de Jong Erik Lubberts Rudi W Hendriks Odilia B J Corneth Source Type: research