A PBPK model for PRRT with [177Lu]Lu-DOTA-TATE: Comparison of model implementations in SAAM II and MATLAB/SimBiology

Radionuclide therapy is an important treatment option for several cancers, but clinical trials and treatments are often based on fixed activities that do not take patient-specific factors into account [1 –3]. For example, for [177Lu]Lu-DOTA-TATE, a fixed activity of 7.4 GBq/cycle for four cycles is used [4,5]. Sometimes, personalised treatment plans based on factors such as body weight or surface area or clinical factors like tumour stage are used [4]. However, absorbed doses (ADs) can vary signi ficantly between patients [6–11].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research