Clinical utility of Next Generation Sequencing of plasma cell-free DNA for the molecular profiling of patients with NSCLC at diagnosis and disease progression

CONCLUSIONS: The present study confirms the potential of liquid biopsy to detect tumour molecular heterogeneity in NSCLC patients at the diagnosis and at PD, demonstrating that a significant number of druggable mutations and mechanisms of resistance can be detected by NGS analysis on ctDNA.PMID:38290249 | PMC:PMC10859238 | DOI:10.1016/j.tranon.2023.101869

Source: Translational Oncology - January 30, 2024 Category: Cancer & Oncology Authors: Marzia Del Re Giovanna Irene Luculli Iacopo Petrini Andrea Sbrana Vieri Scotti Diego de Miguel Perez Lorenzo Livi Stefania Crucitta Mauro Iannopollo Francesca Mazzoni Martina Ruglioni Carmelo Tibaldi Emanuela Olmetto Irene Stasi Editta Baldini Giacomo All Source Type: research