Germline USP36 mutation confers resistance to EGFR-TKIs by upregulating MLLT3 expression in non-small cell lung cancer patients

CONCLUSION: These findings characterized rs3744797 as an oncogenic variant in mediating EGFR-TKIs resistance and tumor aggressiveness through deubiquitinating MLLT3, highlighting the variant as a predictive biomarker for EGFR-TKIs response in NSCLC.PMID:38261467 | DOI:10.1158/1078-0432.CCR-23-2357

Source: Clinical Cancer Research - January 23, 2024 Category: Cancer & Oncology Authors: Shaoxing Guan Xi Chen Yuru Wei Fei Wang Wen Xie Youhao Chen Heng Liang Xia Zhu Yunpeng Yang Wenfeng Fang Yan Huang Hongyun Zhao Xiaoxu Zhang Shu Liu Wei Zhuang Min Huang Xueding Wang Li Zhang Source Type: research