Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice

CONCLUSION: PDK4 inhibition alleviated renal injury with decreased ROS production and inflammation, supporting a critical role for PDK4 in IR mediated damage. This result indicates another potential target for reno-protection during IR injury; accordingly, the role of PDK4 inhibition needs to be comprehensively elucidated in terms of mitochondrial function during renal IR injury.PMID:38311057 | DOI:10.4093/dmj.2023.0196

Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Ah Reum Khang Dong Hun Kim Min-Ji Kim Chang Joo Oh Jae-Han Jeon Sung Hee Choi In-Kyu Lee Source Type: research