Resection of a Large Growing Mediastinal Germ Cell Tumor Using a Multidisciplinary Approach

Curr Oncol. 2023 Dec 21;31(1):42-49. doi: 10.3390/curroncol31010003.ABSTRACTMediastinal germ cell tumors (GCTs) are rare. Post-chemotherapy residual masses in patients with a nonseminomatous GCT require resection. A patient with a large mediastinal GCT involving the left subclavian artery, superior vena cava (SVC) and hilum of the right lung is presented. Despite a biochemical response to chemotherapy, the tumor enlarged on serial imaging. With guidance from medical oncology, a multidisciplinary surgical team, including cardiac anesthesia, cardiac surgery and thoracic surgery resected the tumor with a staged reconstruction of the SVC. The procedure was well tolerated and yielded clear margins. The final pathology showed a significant associated component of rhabdomyosarcoma.PMID:38275829 | PMC:PMC10814761 | DOI:10.3390/curroncol31010003

Source: Current Oncology - January 26, 2024 Category: Cancer & Oncology Authors: Alison Greene Lori Wood Philip Champion Mathieu Castonguay Matthias Scheffler Catherine Deshaies Jeremy Wood Daniel French Source Type: research