Molecular skin fluorescence imaging: A tool for evaluating early melanoma development

Pigment Cell Melanoma Res. 2024 Jan 4. doi: 10.1111/pcmr.13159. Online ahead of print.ABSTRACTA novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% specificity, while identifying dysplastic nevi with the potential for melanoma development.PMID:38178654 | DOI:10.1111/pcmr.13159
Source: Pigment Cell and Melanoma Research - Category: Cytology Authors: Source Type: research