Changes in glutamate and glutamine distributions in the retinas of cystine/glutamate antiporter knockout mice

CONCLUSION: Loss of xCT function results in glutamate metabolic disruption through the accumulation of glutamate in photoreceptors and a reduced uptake of glutamate by Müller cells, which in turn decreases glutamine production. These findings support the idea that xCT plays a role in the presynaptic metabolism of photoreceptors and postsynaptic levels of glutamate and derived neurotransmitters in the retina.PMID:38222448 | PMC:PMC10784226

Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Luis J Knight Renita M Martis Paul J Donaldson Monica L Acosta Julie C Lim Source Type: research