Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition

Conclusion: HnRNP F deficiency in podocytes promotes podocytopathy through activation of Mettl14 expression and its nuclear translocation to inhibit Sirt1 expression, underscoring the protective role of HnRNP F against podocyte injury.PMID:38195017 | DOI:10.1016/j.trsl.2024.01.002

Source: Translational Research : the journal of laboratory and clinical medicine - January 9, 2024 Category: Laboratory Medicine Authors: Min-Chun Liao Chao-Sheng Lo Yu-Chao Pang Wen-Xia Yang Ke Su Xin-Ping Zhao Kana N Miyata Junzheng Peng Julie R Ingelfinger John S D Chan Shao-Ling Zhang Source Type: research