Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia

CONCLUSIONS: The present study identifies ELK1/SND1/SRF as a novel pathway in promoting the proliferative VSMC phenotype and neointimal hyperplasia in vascular injury, predisposing the vessels to pathological remodeling. This provides a potential therapeutic target for vascular stenosis.PMID:38279051 | PMC:PMC10817852 | DOI:10.1007/s00018-023-05095-x

Source: Cellular and Molecular Life Sciences : CMLS - January 26, 2024 Category: Cytology Authors: Chao Su Mingxia Liu Xuyang Yao Wei Hao Jinzheng Ma Yuanyuan Ren Xingjie Gao Lingbiao Xin Lin Ge Ying Yu Minxin Wei Jie Yang Source Type: research