Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine

CONCLUSION: BDNF downregulation mediates synaptic plasticity and excitability damage, leading to cognitive impairments in adulthood following repeated ketamine exposure during the neonatal period.PMID:38332635 | PMC:PMC10853651 | DOI:10.1111/cns.14604

Source: CNS Neuroscience and Therapeutics - February 9, 2024 Category: Neuroscience Authors: Jie Wan Linhui Ma Xinhao Jiao Wei Dong Jiatao Lin Yongkang Qiu Weifeng Wu Qiang Liu Chen Chen He Huang Shuai Li Hui Zheng Yuqing Wu Source Type: research