The intersection between host-pathogen interactions and metabolism during Vibrio cholerae infection

Curr Opin Microbiol. 2024 Feb;77:102421. doi: 10.1016/j.mib.2023.102421. Epub 2024 Jan 11.ABSTRACTVibrio cholerae (V. cholerae), the etiological agent of cholera, uses cholera toxin (CT) to cause severe diarrheal disease. Cholera is still a significant cause of mortality worldwide with about half of all cholera cases and deaths occurring in children under five. Owing to the lack of cost-effective vaccination and poor vaccine efficacy in children, there is a need for alternative preventative and therapeutic strategies. Recent advances in our knowledge of the interplay between CT-induced disease and host-pathogen metabolism have opened the door for investigating how modulation of intestinal metabolism by V. cholerae during disease impacts host intestinal immunity, the gut microbiota, and pathogen-phage interactions. In this review article, we examine recent progress in our understanding of host-pathogen interactions during V. cholerae infection and discuss future work deciphering how modulation of gut metabolism during cholera intersects these processes to enable successful fecal-oral transmission of the pathogen.PMID:38215547 | DOI:10.1016/j.mib.2023.102421
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Source Type: research