HIV-1-induced translocation of CPSF6 to biomolecular condensates

Trends Microbiol. 2024 Jan 23:S0966-842X(24)00001-5. doi: 10.1016/j.tim.2024.01.001. Online ahead of print.ABSTRACTCleavage and polyadenylation specificity factor subunit 6 (CPSF6, also known as CFIm68) is a 68 kDa component of the mammalian cleavage factor I (CFIm) complex that modulates mRNA alternative polyadenylation (APA) and determines 3' untranslated region (UTR) length, an important gene expression control mechanism. CPSF6 directly interacts with the HIV-1 core during infection, suggesting involvement in HIV-1 replication. Here, we review the contributions of CPSF6 to every stage of the HIV-1 replication cycle. Recently, several groups described the ability of HIV-1 infection to induce CPSF6 translocation to nuclear speckles, which are biomolecular condensates. We discuss the implications for CPSF6 localization in condensates and the potential role of condensate-localized CPSF6 in the ability of HIV-1 to control the protein expression pattern of the cell.PMID:38267295 | DOI:10.1016/j.tim.2024.01.001
Source: Trends in Microbiology - Category: Microbiology Authors: Source Type: research