Viruses, Vol. 16, Pages 303: Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus

Viruses, Vol. 16, Pages 303: Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus Viruses doi: 10.3390/v16020303 Authors: Émilie Nantel Marie-Hélène Mayrand François Audibert Joseph Niyibizi Paul Brassard Louise Laporte Julie Lacaille Monica Zahreddine William Fraser Diane Francoeur Marie-Josée Bédard Isabelle Girard Jacques Lacroix Ana Maria Carceller François Coutlée Helen Trottier Human papillomavirus (HPV) can be vertically transmitted. Our objective was to measure the association between the mode of delivery and the detection of HPV in infants. We used data collected from pregnant women during the HERITAGE study. Self-collected vaginal samples from the first and third trimester were obtained for HPV testing. Specimens from oral, pharyngeal, conjunctival and anogenital mucosa were collected from infants 36–48 h after delivery and at 3 months of age. All samples were tested for HPV DNA by the Linear Array assay. Adjusted odd ratios (aOR) and 95% confidence interval (CI) were estimated using multivariate logistic regressions. From the 282 women revealed to be HPV-positive in both the first and third trimesters, 25 infants were born HPV-positive. The overall probability of transmission was 8.9% (25/282); 3.7% (3/81) in participants with a caesarean section and 10.9% (22/201) for those who delivered vaginally. Vaginal delivery increased the risk of HPV in infants compared to caes...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research