BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1

In conclusion, BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1. This indicates that modulating BRG1-OXR1-mitophagy signaling may represent an effective treatment for PD-related peritoneal fibrosis.PMID:38311259 | DOI:10.1016/j.freeradbiomed.2024.01.054

Source: Free Radical Biology and Medicine - February 4, 2024 Category: Biology Authors: Shuting Li Yiyi Zhuang Yue Ji Xiaowen Chen Liying He Sijia Chen Yating Luo Lingyu Shen Jing Xiao Huizhen Wang Congwei Luo Fenfen Peng Haibo Long Source Type: research