Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis

Mini Rev Med Chem. 2024 Jan 26. doi: 10.2174/0113895575273164231130070920. Online ahead of print.ABSTRACTSince ferroptosis was reported in 2012, its application prospects in various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis. The primary mechanism is to affect the occurrence and development of atherosclerosis through intracellular iron homeostasis, ROS and lipid peroxide production and metabolism, and a variety of intracellular signaling pathways. Inhibition of ferroptosis is effective in inhibiting the development of atherosclerosis, and it can bring a new direction for treating atherosclerosis. In this review, we discuss the mechanism of ferroptosis and focus on the relationship between ferroptosis and atherosclerosis, summarize the different types of ferroptosis inhibitors that have been widely studied, and discuss some issues worthy of attention in the treatment of atherosclerosis by targeting ferroptosis.PMID:38284727 | DOI:10.2174/0113895575273164231130070920

Source: Mini Reviews in Medicinal Chemistry - January 29, 2024 Category: Chemistry Authors: Yifan Zhang Chengshi Jiang Ning Meng Source Type: research