Pharmacokinetic study of osilodrostat and identification of mono-hydroxylated metabolite in equine plasma for the purpose of doping control

CONCLUSIONS: For doping control, screening of both the parent drug osilodrostat and its mono-hydroxylated metabolite in equine plasma would be recommended due to their extended detection windows of up to 2 weeks. Given the availability of reference material for potential confirmation in forensic samples, osilodrostat is considered the most appropriate monitoring target.PMID:38355879 | DOI:10.1002/rcm.9695

Source: Rapid Communications in Mass Spectrometry : RCM - February 14, 2024 Category: Chemistry Authors: Hideaki Ishii Yuhiro Ishikawa Fumiaki Mizobe Motoi Nomura Takashi Yamanaka Sohei Tanabe Shun-Ichi Nagata Masayuki Yamada Gary Ngai-Wa Leung Source Type: research