Splicing DNA Damage Adaptations for the Management of Cancer Cells

Curr Gene Ther. 2024;24(2):135-146. doi: 10.2174/0115665232258528231018113410.ABSTRACTMaintaining a tumour cell's resistance to apoptosis (organized cell death) is essential for cancer to metastasize. Signal molecules play a critical function in the tightly regulated apoptotic process. Apoptosis may be triggered by a wide variety of cellular stresses, including DNA damage, but its ultimate goal is always the same: the removal of damaged cells that might otherwise develop into tumours. Many chemotherapy drugs rely on cancer cells being able to undergo apoptosis as a means of killing them. The mechanisms by which DNA-damaging agents trigger apoptosis, the interplay between pro- and apoptosis-inducing signals, and the potential for alteration of these pathways in cancer are the primary topics of this review.PMID:38282448 | DOI:10.2174/0115665232258528231018113410
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research