Activation of farnesoid X receptor retards expansion of renal collecting duct cells-derived cysts via inhibition of CFTR-mediated Cl < sup > - < /sup > secretion

This study shows that FXR activation inhibits Cl- secretion in renal cells via inhibition of CFTR expression and retards renal cyst formation and growth. The discoveries point to a physiological role of FXR in the regulation of CFTR and a potential therapeutic application in polycystic kidney disease treatment.PMID:38299213 | DOI:10.1152/ajprenal.00363.2023
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Source Type: research