Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model

In conclusion, quantitative simulation using the PBPK model suggests the feasibility of the safe repositioning of tipepidine as a once-daily medication in combination with quinidine.PMID:38193900 | DOI:10.1080/00498254.2024.2304129

Source: Xenobiotica - January 9, 2024 Category: Research Authors: Shun Hayashi Hiroko Kawaguchi Takao Watanabe Izuru Miyawaki Tatsuki Fukami Miki Nakajima Source Type: research