Left Atrial Strain in Multisystem Inflammatory Syndrome in Children and Associations with Systemic Inflammation and Cardiac Injury

AbstractMultisystem inflammatory syndrome in children (MIS-C) commonly involves cardiac injury with both systolic and diastolic dysfunction. Left atrial strain (LAS) detects subclinical diastolic dysfunction in adults but is infrequently used in children. We evaluated LAS in MIS-C and the associations with systemic inflammation and cardiac injury. In this retrospective cohort study, LAS parameters [reservoir (LAS-r), conduit (LAS-cd), and contractile (LAS-ct)] obtained from admission echocardiograms of MIS-C patients were compared to healthy controls and between MIS-C patients with and without cardiac injury (BNP  >  500 pg/ml or troponin-I >  0.04 ng/ml). Correlation and logistic regression analyses were performed to assess LAS associations with admission inflammatory and cardiac biomarkers. Reliability testing was performed. We identified 118 patients with MIS-C and 20 healthy controls. Median LAS parameters were reduced in MIS-C pa tients compared to controls (LAS-r: 31.8 vs. 43.1%,p <  0.001; LAS-cd: − 28.8 vs. − 34.5%,p = 0.006; LAS-ct: − 5.2 vs. − 9.3%,p <  0.001) and reduced in MIS-C patients with cardiac injury (n = 59) compared to no injury (n = 59) (LAS-r: 29.6 vs. 35.8%,p = 0.001; LAS-cd: − 26.5 vs. − 30.4%,p = 0.036; LAS-ct: − 4.6 vs. − 9.3%,p = 0.008). A discrete LAS-ct peak was absent in 65 (55%) MIS-C patients but present in all controls (p <  0.001). Procalcitonin correlated s...

Source: Mammalian Genome - February 15, 2024 Category: Genetics & Stem Cells Source Type: research