Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43

CONCLUSIONS: This is the first report to demonstrate of the protective effect of SCFAs on microbial keratitis, and the dynamic expression and anti-inflammatory function of GPR43 in the eye. SCFAs can modulate inflammation and immunity in the eye through GPR43.PMID:38224777 | DOI:10.1016/j.jtos.2024.01.005

Source: The Ocular Surface - January 15, 2024 Category: Opthalmology Authors: Jun Wu Nu Chen Elizabeth Grau Luke Johnson Yongqing Liu Chi Li Patrick A Scott Chang Kim Deming Sun Henry J Kaplan Hui Shao Source Type: research